About Us > Faculty & Staff > Faculty > Scott Tenenbaum
Associate Professor of Nanobioscience
Dr. Scott Tenenbaum Discusses Nanobioscience at CNSE
Read Professor Tenebaum's Nanotechnology Now Column: Using Nanotechnology to Study the Human Genome
- Postdoctoral Fellow, Duke University Medical Center, Durham, NC, 2003
- Postdoctoral Fellow, Tulane University Medical Center, New Orleans, LA, 1997
- Ph.D., Microbiology and Immunology, Tulane University, New Orleans, LA, 1994
Assistant Professor, Department of Biomedical sciences, University at Albany - State University of New York, Rensselaer, NY, 2003-2009
Senior Research Associate, Department of Molecular Microbiology and Genetics, Duke University Medical Center, Durham, NC, 2000-2003
Research Website: http://www.albany.edu/cancergenomics/faculty/stenenbaum/index.shtml
Areas of Research
Studying the mRNP Regulatory Code
Development of a high-throughput nanoscale immunoassay platform
Development of an Anti-Viral Therapeutic Technology
Development of Data Mining Software
Prostate Cancer Therapy Drug Study
- Single-cell Nanotube sensors
- Cancer metastasis diagnostics
- RNA-based therapeutics
Dr. Tenenbaum's research focuses on understanding some of the basic aspects of how the human genome works; specifically post-transcriptional gene regulation. Along with his research team, Dr. Tenenbaum has helped to advance cutting-edge technology and computer-based informatic approaches to studying RNA biology, specifically RNA-binding proteins, to aggressively study and better understand these molecules that regulate information contained in RNA. Dr. Tenenbaum's research methods also include working on nano-based technology to make the research more robust. Dr. Tenenbaum is involved with HocusLocus Inc., a biotechnology based start-up company that was spun-out of UAlbany. HocusLocus is working to commercialize some of the technology, which is regularly used for drug-target discovery and studying the effects of an anti-hormone drug on the growth of prostate cancer cells, among other research initiatives.
Recent Honors and Awards:
- Excellence in Research Award, University at Albany
Rising Star Award, The Research Foundation of SUNY
Golden Apple Teaching Award, UAlbany School of Public Health
Robert & Barbara Bell Science of Cancer Award, Duke Comprehensive Cancer Center
James A. Wilson, M.D. Fellow in Cancer Award, Duke Comprehensive Cancer Center
Dutasteride monotherapy in men with serologic relapse following radical therapy for adenocarcinoma of the prostate: A pilot study. Perrotti M, Jain R, Abriel LM, Baroni TE, Corbett AB, Tenenbaum SA. Urol Oncol. 2010 Aug 25.
RIP-CHIP in drug development. Jain R, Doyle F, George AD, Kuentzel M, Frank D, Chittur SV, Tenenbaum SA. Methods Mol Biol. 2010;632:159-7
Informatic resources for identifying and annotating structural RNA motifs. George AD, Tenenbaum SA. Mol Biotechnol. 2009 Feb;41(2):180-93.
George, A.D., and Tenenbaum, S.A. (2008). Informatic Resources for Identifying and Annotating Structural RNA Motifs. Mol Biotechnol. 2008 Nov 1. [Epub ahead of print]
Baroni, T. E., Chittur, S. V., George, A. D. and Tenenbaum, S. A. (2008). Advances in RIP-Chip Analysis: RNA-Binding Protein Immunoprecipitation-Microarray (Chip) Profiling. Methods Mol Biol. 2008;419:93-108.
Stoecklin G, Tenenbaum S. A., Mayo T, Chittur SV, George AD, Baroni TE, Blackshear PJ and Anderson, P. (2008). Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin. J Biol Chem. Apr 25;283(17):11689-99.
Doyle, F., Zaleski, C., George, A.D., Stenson, E.K., Ricciardi, A. and Tenenbaum, S. A. (2008). Bioinformatic Tools for Studying Post-Transcriptional Gene Regulation: The UAlbanyTUTR (Training UTR) Collection and other Informatic Resources. Methods Mol Biol. 2008;419:39-52.
Mazroui R, Di Marco S, Clair E, von Roretz C, Tenenbaum S. A., Keene JD, Saleh M, Gallouzi IE. (2008). Caspase-7-mediated Cleavage of the RNA-binding Protein HuR is a Novel Regulatory Mechanism Required for Apoptosis. J Cell Biol. 180(1):113-27.
Baroni, T. E., Lastro, M. T., Ranganathan, A. C., Tenenbaum, S. A., Conklin, D. S. and Aguirre-Ghiso, J. A. (2007). Ribonomic and Short Hairpin RNA Gene Silencing Methods to Explore Functional Gene Programs Associated with Tumor Growth Arrest Methods in Molecular Biology: Cancer Genomics and Proteomics vol.383: 227-244.
George, A.D., and Tenenbaum, S.A. (2006). MicroRNA Modulation of RNA-Binding Protein Regulatory Elements. RNA Biology 3(2): 1-4.
Tenenbaum, S. A. and Aguirre-Ghiso, J.A. (2005). Dephosphorylation Shows SR Proteins the Way Out. Mol. Cell. 23;20(4):499-501.
Sander DM, Szabo S, Gallaher WR, Deas JE, Thompson JJ, Cao Y, Luo-Zhang H, Liu LG, Colmegna I, Koehler J, Espinoza LR, Alexander SS, Hart DJ, Tom DM, Fermin CD, Jaspan JJ, Kulakosky PC, Tenenbaum S.A., Wilson RB, Garry RF. (2005). Involvement of human intracisternal A-type retroviral particles in autoimmunity. Microsc Res Tech. 68:222-34.
Tenenbaum S.A., Morris CA, Alexander SS, McFerrin HE, Garry RF, Leissinger CA. (2005). Evidence of HIV exposure and transient seroreactivity in archived HIV-negative severe hemophiliac sera. Virol J. 17; 2:65.
Di-Marco, S., Mazroui, R., Dallaire, P., Chittur, S., Tenenbaum, S.A., Radzioch, D., Marette A., and Gallouzi, I.E. (2005). NF-kB-Mediated MyoD Decay during Muscle Wasting Requires Nitric Oxide Synthase mRNA Stabilization, HuR Protein, and Nitric Oxide Release. Mol Cell Biol. 15: 6533-45.
Penalva, L.O., Tenenbaum, S.A., and Keene, J.D. (2004). Gene Expression Analysis of Messenger RNP Complexes. Methods Mol Biol. 257:125-34.
Intine, R.V., Tenenbaum, S.A., Sakulich, A.L., Keene, J.D., and Maraia, R.J. (2003). Differential phosphorylation and subcellular localization of LaRNPs associated with precursor tRNAs and translation-related mRNAs. Molecular Cell 12: 1301-1307. Tenenbaum, S.A.
, Carson C.C., Atasoy, U., and Keene, J.D. (2003
). Combining en masse
array analysis of gene regulation using genome-wide approaches to nuclear run-ons (em
RON) and mRNP isolation (ribonomics). Gene
Tenenbaum, S.A., Hauser, J.M., Castracane, J., Tokranova, N., Padgen, M.R. and Baroni, T. High-Throughput Nanoscale Immunoassy Platform. Provisional Patent Application # 61138391
Tenenbaum, S.A., Zaleski, C., George, A.D., and Doyle, F. Non-Random Control Data Set Generation for Facilitating Genomic Data Processing. Provisional Patent Application # 60/917,158 (Pending license to HocusLocus, LLC, Rensselaer, NY). Filed 2007.
Tenenbaum, S.A., Zaleski, C., George, A.D., and Doyle, F. Segmented Storage and Retrieval of Nucleotide Sequence Information. Provisional Patent Application # 60/917,157 (Pending license to HocusLocus, LLC, Rensselaer, NY). Filed 2007.
Tenenbaum, S.A., Zaleski, C., George, A.D., and Doyle, F. Genomic Data Processing Utilizing Correlation Analysis of Nucleotide Loci of Multiple Data Sets. Patent Application # 60/917,156 (Pending license to HocusLocus, LLC, Rensselaer, NY). Filed 2007.
Tenenbaum, S.A., Zaleski, C., George, A.D., and Doyle, F. Genomic Data Processing Utilizing Correlation Analysis of Nucleotide Loci. Provisional Patent Application # 60/917,155 (Pending license to HocusLocus, LLC, Rensselaer, NY), Filed 2007.
Tenenbaum, S.A., Conklin, D.S., Kourtidis, A., George, A.D., Zaleski, C., Baroni, T., and Doyle, F. Compositions and Methods for Treating Viral Infections. Provisional Patent Application # 61/023,933 (Pending license to HocusLocus, LLC, Rensselaer, NY). Filed 2008.
Warren, S.T., Brown-kennerly, V., Jin, P., Ceman, S., Darnell, R.B., Darnell, J.C., Keene, J.D., and Tenenbaum, S. A. Method and identification of downstream mrna ligands to fmrp and their role in fragile x syndrome and associated disorders. USP# 7432052.
Keene, J.D., Carson, C.C. and Tenenbaum, S.A. Methods for the Endogenous Isolation and Identification of Messenger RNA Subsets. USP# 6,635,422 (Licensed to Ribonomics Inc., Triangle Park, NC).
Garry, R.F., Tenenbaum, S. A., and Plymale, D. R. Method to Aid in the Diagnosis of Silicone Related Disease. USP# 5,620,859 (Licensed to Autoimmune Inc., New Orleans, LA).
Garry, R.F., Tenenbaum, S. A., and Plymale, D. R. Method for detecting antipolymer antibodies and diagnosing silicone related disease (SRD) fibromyalgia and chronic fatigue syndrome (CFS). USP#5834215 (Licensed to Autoimmune Inc., New Orleans, LA, International patent pending).
Recent Invited Lectures and Presentations
- Nanomedicine Development Center, University of Cincinnati, Cincinnati, OH, 2010
- Children's Cancer Research Institute - UTHSCSA, San Antonio, TX, 2010
- The ENCODE Project, Barcelona, Spain, 2010
- Sanford Burnham Institute, Orlando FL, 2010
- Sigma Aldrich, St. Louis, MO, 2010
- Cell Culture Engineering XII, Fairmont Banff Springs Hotel, Banff, Alberta, Canada, 2010
- Systems Biology Meeting, Cold Spring Harbor, NY, 2010
- Millipore Future Forum II, Bedford, MA, 2010
- Systems Biology of Human Aging Symposium, NIA/NIH, Baltimore, MD, 2009
- Boston College, Department of Biology, Boston, MA, 2009
- Millipore Future Forum, Boston, MA, 2009
- Millipore BioAsia Tour, Tokyo, Japan, Seoul, Korea and Shanghai, China, 2009
- University of Toronto, Institute of Biomaterials & Biomedical Engineering, Toronto, Canada, 2009
- Yale University Medical Center, Department of Hematology, New Haven, CT FASEB Meeting Post-transcriptional Control of Gene Expression, Lucca, Italy, 2008
- The Biology of Genomes Meeting, Cold Spring Harbor, NY, 2008
Workshop on Post-transcriptional regulation of viral gene expression, Syria, VA, 2008
modENCODE/ENCODE Joint Consortium Workshop, Bethesda, MD, 2008
Harvard Medical School, Department of Systems Biology, Cambridge, MA, 2007
The 12th Annual RNA Society Conference, Madison, WI, 2007
Systems Biology Meeting, Cold Spring Harbor, NY, 2007
New York Academy of Sciences, New York, NY, 2007
Kavli Institute for Theoretical Physics, Santa Barbara, CA, 2007
Boston University Medical Center, Department of Pulmonology, Boston, MA, 2007
University of Pennsylvania Medical Center, Dept. of Pharmacology, Philadelphia, PA, 2006
Genomic Institute of Singapore, Department of Systems Biology, Singapore, 2006
Institute for Immunologic Studies, Kyoto University, Japan, 2006
Center for Genomics and Systems Biology, Tokyo University, Japan, 2006
I2CAM Landscape Networks Meeting, Telluride, CO, 2006
Advances in Functional Genomics Conference, San Francisco, CA, 2006
University of Calgary, Department of Rheumatology, Alberta, Canada, 2006